Physiochemical Profiling
Lipophilicity and solubility are two essential factors, which directly influence absorption, distribution, and overall pharmacokinetic behavior.
Explore capabilityAnalytical & DMPK
Drug Metabolism & PK (DMPK)
Explore the ADME and pharmacokinetic properties of your candidates with integrated in-vitro and in-vivo studies.
- ADME-Tox
- Metabolic stability
- DDI
The science
Service overview
We provide comprehensive in vitro and in vivo DMPK studies to evaluate how a drug is absorbed, distributed, metabolized, and excreted (ADME).
How we can help
Our capabilities
Explore the services and methods available for your project.
Chemical and Metabolic Stability
Early-stage drug discovery tool used to evaluate how a compound resists degradation and biotransformation in biological systems.
Explore capabilityDrug-Drug Interaction (DDI) Studies
Essential in-vitro and in-vivo testing, modeling, and clinical trials to assess how investigational drugs interact with other compounds.
Explore capabilityIn-vitro Permeability
Comprehensive ADME-Tox services to evaluate how drug compounds cross biological barriers (skin, intestines, blood-brain barrier).
Explore capabilityIn-vivo Pharmacokinetic (PK) and Pharmacodynamic (PD)
Evaluating how a drug moves through a living system and its biological effect, using animal models (mice, rats) for dose-response and safety.
Explore capabilityDMPK Consultancy
DMPK consultancy from Hit ID right through to clinical trial phase I and II, with specialized input into CNS discovery projects.
Explore capabilityHow a project runs
Research workflow
4 stages, with a clear outcome at each step.
Physiochemical & In-Vitro ADME Screening
Evaluating lipophilicity, solubility, microsomal stability, plasma protein binding, and in-vitro permeability.
Outcome: In-Vitro ADME
MetID & Drug-Drug Interaction Studies
Assessing metabolic pathways (MetID), recombinant enzyme/transporter assays, and DDI interaction risks.
Outcome: MetID & DDI
In-Vivo PK/PD & Blood-to-Plasma Partitioning
Evaluating absorption, clearance, bioavailability, and blood-to-plasma partition ratio in animal models (mice, rats).
Outcome: In-Vivo PK/PD
PBPK Modeling & Expert DMPK Consultancy
Predicting human PK via PBPK modeling and providing independent expert consultancy through Phase I/II clinical trials.
Outcome: PBPK & Clinical Plan
Explore in detail
Technical resources
Open a section to explore our full service scope and instrumentation.
Methods & service scope5 areas of expertise
- Physiochemical Profiling
Evaluating lipophilicity and solubility factors influencing absorption, distribution, and overall PK behavior.
- Chemical & Metabolic Stability
Early-stage drug discovery tool evaluating compound resistance to degradation and biotransformation.
- Drug-Drug Interaction (DDI) Studies
In-vitro and in-vivo testing, modeling, and clinical trials to assess drug interaction.
- In-vitro Permeability & ADME-Tox
Evaluating biological barrier crossing (skin, intestines, BBB) to determine absorption and bioavailability.
- In-vivo PK / PD & Blood-to-Plasma Partition
Evaluating drug movement through living systems and erythrocyte binding.
Instrumentation & platforms5 instruments and capabilities
- High-Resolution Mass Spectrometry (HRMS) - (i.e., Orbitrap or Q-TOF systems)
- Automated Liquid Handling Platforms - For high-throughput in vitro ADME assays
- Recombinant Enzyme & Transporter Assay Platforms
- Physiologically Based Pharmacokinetic (PBPK) Modeling Software
- 3D Cell Culture and Organ-on-a-Chip Suites
Let’s work together
The right expertise.
For your next step.
Talk with our scientific team about your requirements,
technical feasibility, and timelines.
What happens next
- Share your requirementsTell us about your research goals, scope, and timelines.
- Scientific consultationOur scientists review feasibility and discuss the best approach with you.
- Proposal and quoteReceive a clear proposal covering scope, deliverables, timelines, and cost.