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Chemistry R&D

API Physico-Chemical Testing

Characterize and optimize the physical and chemical properties of your active pharmaceutical ingredients.

  • Solid-state
  • Crystal engineering
  • PAT
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The science

Service overview

We provide physicochemical testing and experimental services designed to enhance the stability, solubility, and bioavailability of Active Pharmaceutical Ingredients (APIs). The ability to deliver drug products to patients in a safe, efficient, and cost-effective manner depends largely on the physicochemical properties of the API in the solid state. The pharmaceutical industry has encountered a large number of drugs with poor physicochemical properties, leading to variable pharmacokinetic properties that made them unsuitable for marketing as drug products. Our pharmaceutical development scientists can help you optimize these API properties using up-to-date techniques such as co-crystallization, crystallization, and salt screening.

How we can help

Our capabilities

Explore the services and methods available for your project.

Physicochemical Assessment & Property Screening

Evaluating API purity, pKa, partition coefficient, solubility, dissolution, particle size, and stability under manufacturing conditions.

Process Analytical Technology (PAT)

Real-time analysis of polymorph form and API-polymer interaction using Raman / FT-IR Spectroscopy, solid-state form identification via XRPD, and in-line crystal size and count tracking via FBRM.

Advanced Formulation & Encapsulation Technologies

Producing amorphous high-surface-area powders via Lyophilization (Freeze Drying), encapsulating APIs in Liposomes & Micelles, and cost-effective preparation of ASDs via Controlled API-Polymer Solidification (CAPS).

Solid-State Modification & Crystal Engineering

Improving solubility without changing chemical structure via Co-crystals, enhancing flowability/compressibility via Spherical Crystallization, controlling polymorphs, and preparing Amorphous Solid Dispersions (ASDs) via Hot-Melt Extrusion (HME).

Inside our laboratory

The instruments behind your results

Full instrument list

Explore in detail

Technical resources

Open a section to explore our full service scope and instrumentation.

Methods & service scope9 areas of expertise
  • API purity and related substances
  • Partition coefficient
  • Acidity constant (pKa)
  • Solubility/ Dissolution
  • Particle size/ Surface area
  • Crystal properties - crystallinity, polymorphism
  • Chemical stability
  • Physical stability
  • Compatibility with excipients
Instrumentation & platforms7 instruments and capabilities
  • Raman / FT-IR Spectroscopy / FTIR: Real-time analysis of polymorph form and API-polymer interaction
  • X-Ray Powder Diffraction (XRPD): Critical for identifying solid-state forms
  • Focused Beam Reflectance Measurement (FBRM): In-line tracking of crystal size and count
  • Lyophilization (Freeze Drying) Workstations
  • Hot-Melt Extrusion (HME) Equipment for ASDs
  • Co-crystallization, Crystallization & Salt Screening Platforms
  • Liposomes and Micelles Encapsulation Systems

Let’s work together

The right expertise.
For your next step.

Talk with our scientific team about your requirements,
technical feasibility, and timelines.

Discuss your project
+1 604-339-3244

What happens next

  1. Share your requirementsTell us about your research goals, scope, and timelines.
  2. Scientific consultationOur scientists review feasibility and discuss the best approach with you.
  3. Proposal and quoteReceive a clear proposal covering scope, deliverables, timelines, and cost.