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Specialist expertise

In-vitro Permeability

Evaluating absorption, bioavailability, and barrier crossing (skin, intestines, BBB).

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The science

About this capability

We offer comprehensive ADME-Tox services to evaluate how drug compounds cross biological barriers (skin, intestines, blood-brain barrier) to determine absorption, bioavailability, and transporter-mediated interactions.

Technical scope

  • Blood-brain barrier (BBB) permeability (MDR1-MDCK / PAMPA-BBB)
  • Caco-2 and MDCK intestinal absorption assays
  • Skin penetration evaluations (IVPT)
  • Transporter-mediated absorption & efflux (P-gp, BCRP)

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Physiochemical Profiling

Lipophilicity and solubility are two essential factors, which directly influence absorption, distribution, and overall pharmacokinetic behavior.

Chemical and Metabolic Stability

Early-stage drug discovery tool used to evaluate how a compound resists degradation and biotransformation in biological systems.

Drug-Drug Interaction (DDI) Studies

Essential in-vitro and in-vivo testing, modeling, and clinical trials to assess how investigational drugs interact with other compounds.

In-vivo Pharmacokinetic (PK) and Pharmacodynamic (PD)

Evaluating how a drug moves through a living system and its biological effect, using animal models (mice, rats) for dose-response and safety.

DMPK Consultancy

DMPK consultancy from Hit ID right through to clinical trial phase I and II, with specialized input into CNS discovery projects.

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The right expertise.
For your next step.

Talk with our scientific team about your requirements,
technical feasibility, and timelines.

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+1 604-339-3244

What happens next

  1. Share your requirementsTell us about your research goals, scope, and timelines.
  2. Scientific consultationOur scientists review feasibility and discuss the best approach with you.
  3. Proposal and quoteReceive a clear proposal covering scope, deliverables, timelines, and cost.