Upstream & Downstream Development
Optimization of microbial fermentation, cell culture, and purification processes (e.g., depth filtration, chromatography) to increase yield and product quality.
Chemistry R&D
Process Development & Scale-Up
Develop and optimize synthetic routes as your program moves from laboratory research toward larger-scale production.
- Route optimization
- DoE
- Scale-up
The science
Service overview
We transform laboratory-scale chemistry into robust, reproducible processes for material supply, delivering data-driven solutions that keep your process performing from discovery through manufacture. Process development and scale-up are essential to a competitive commercial product. Our scientists conduct rapid process development, optimize reaction conditions, and scale up materials for preclinical studies or large-scale manufacturing, taking a pragmatic approach even on the most challenging projects. We assess route feasibility, risk, and cost to identify the most efficient and scalable pathway for your molecule.
How we can help
Our capabilities
Explore the services and methods available for your project.
Formulation Development
Pre-formulation studies, solubility enhancement, and specialized technology application.
Quality by Design (QbD)
Using experimental design techniques (DoE) to identify Critical Process Parameters (CPPs) and Critical Quality Attributes (CQAs) to ensure robust performance.
How a project runs
Research workflow
4 stages, with a clear outcome at each step.
Route Feasibility & Risk Assessment
Assessing synthetic route feasibility, risk, cost, and evaluating target molecule pathways.
Outcome: Route Feasibility
DoE Reaction Optimization & Parallel Screening
Optimizing reaction conditions via statistical Design of Experiments (DoE) and parallel equipment screening.
Outcome: DoE Optimization
Upstream/Downstream & QbD Implementation
Optimizing microbial fermentation, cell culture, filtration/chromatography, and identifying CPPs/CQAs.
Outcome: QbD Process Parameters
In-Process Testing & Process Safety Scale-Up
Establishing in-process analytical methods, conducting Process Safety Assessment, and scaling up materials for clinical trials.
Outcome: Clinical Batch Scale-Up
Explore in detail
Technical resources
Open a section to explore our full service scope and instrumentation.
Methods & service scope4 areas of expertise
- Synthetic Route Evaluation & Methodology Development
Synthetic route evaluation and development of new methodologies for target molecules to identify the most scalable pathway.
- Reaction Condition Optimization (DoE)
Optimization of reaction conditions to reduce cost & maximize throughput by classical methods or statistical design of experiments (DoE).
- Cryogenic & High-Pressure Reaction Capabilities
Ability to perform synthetic work under extreme cryogenic conditions (-78 °C) or high pressures (>100 psi).
- In-Process Testing & Process Safety Assessment
Development of reliable in-process testing methods for intermediates/APIs, rapid parallel screening, and comprehensive Process Safety Assessments.
Instrumentation & platforms6 instruments and capabilities
- Parallel Reaction Screening Workstations
- Cryogenic Reaction Equipment (-78 °C)
- High-Pressure Reactors (>100 psi)
- Microbial Fermentation & Cell Culture Upstream Units
- Depth Filtration & Chromatography Downstream Systems
- Process Safety Assessment Calorimeters & Analytical In-Process Testing Suite
Let’s work together
The right expertise.
For your next step.
Talk with our scientific team about your requirements,
technical feasibility, and timelines.
What happens next
- Share your requirementsTell us about your research goals, scope, and timelines.
- Scientific consultationOur scientists review feasibility and discuss the best approach with you.
- Proposal and quoteReceive a clear proposal covering scope, deliverables, timelines, and cost.