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Specialist expertise

Chemical and Metabolic Stability

Evaluating compound degradation and biotransformation in biological systems.

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The science

About this capability

This is an early-stage drug discovery tool used to evaluate how a compound resists degradation and biotransformation in biological systems.

Technical scope

  • Microsomal stability assays across species (human, rat, mouse)
  • Hepatocyte metabolic screening and clearance prediction
  • Plasma protein binding (equilibrium dialysis / ultrafiltration)
  • Biotransformation & degradation tracking

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Physiochemical Profiling

Lipophilicity and solubility are two essential factors, which directly influence absorption, distribution, and overall pharmacokinetic behavior.

Drug-Drug Interaction (DDI) Studies

Essential in-vitro and in-vivo testing, modeling, and clinical trials to assess how investigational drugs interact with other compounds.

In-vitro Permeability

Comprehensive ADME-Tox services to evaluate how drug compounds cross biological barriers (skin, intestines, blood-brain barrier).

In-vivo Pharmacokinetic (PK) and Pharmacodynamic (PD)

Evaluating how a drug moves through a living system and its biological effect, using animal models (mice, rats) for dose-response and safety.

DMPK Consultancy

DMPK consultancy from Hit ID right through to clinical trial phase I and II, with specialized input into CNS discovery projects.

Let’s work together

The right expertise.
For your next step.

Talk with our scientific team about your requirements,
technical feasibility, and timelines.

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+1 604-339-3244

What happens next

  1. Share your requirementsTell us about your research goals, scope, and timelines.
  2. Scientific consultationOur scientists review feasibility and discuss the best approach with you.
  3. Proposal and quoteReceive a clear proposal covering scope, deliverables, timelines, and cost.