Milligram to Kilogram Synthesis
High-purity custom compounds from milligram research quantities to multi-kilogram scale, with larger batches supported by our process development team.
Chemistry R&D
Custom Synthesis
Custom synthesis of high-purity compounds, reference standards, and intermediates, from milligrams to kilograms.
- mg to kg scale
- Reference standards
- Intermediates
The science
Service overview
We synthesize high-purity custom compounds across a broad range of chemical classes, from milligram research quantities to multi-kilogram scale. Biotech, pharmaceutical, and university researchers rely on our pragmatic wet chemistry expertise for timely delivery of reference standards, intermediates, building blocks, impurities, and metabolites, with strict confidentiality and competitive pricing.
How we can help
Our capabilities
Explore the services and methods available for your project.
Synthetic Route Design
We follow published or client-provided procedures, or design a fast, cost-effective new route when none is known.
Methods & details
- Literature and patent searches in SciFinder and Reaxys
- Published or client-provided synthetic procedures
- New routes designed for speed and cost
- Troubleshooting of existing synthetic pathways
Reference Standards
Reference compounds for bioassays and analytical work, from a few milligrams to 100 g.
Methods & details
- Stable isotope-labelled standards (D, ¹³C, ¹⁵N)
- Bioassay reference standards and test articles
- Active pharmaceutical ingredients (APIs) and API analogues
- API metabolites and impurities
Chemical Intermediates
Research and key intermediates for pharmaceutical and agrochemical programs, prepared by known routes, your protocols, or a newly designed route.
Scaffolds & Building Blocks
Organic scaffolds and building blocks from a few milligrams to hundreds of grams, on an exclusive, partially exclusive, or non-exclusive basis.
Methods & details
- Core scaffolds and building blocks
- Fragment libraries and screening compounds
- Research intermediates and biochemicals
Impurities & Metabolites
Synthesis of process impurities, degradation products, and drug metabolites to support impurity identification and ADME-Tox studies.
Methods & details
- Process impurities and degradation products
- Drug metabolites
- Material for ADME-Tox and mechanism-of-action studies
How a project runs
Research workflow
5 stages, with a clear outcome at each step.
Literature Search & Route Design
Searching SciFinder and Reaxys for known procedures, or designing a fast, cost-effective route when none is published.
Outcome: Route Design
Synthesis
Pragmatic wet chemistry across a broad range of compound classes and reaction types, from milligram to multi-kilogram scale.
Outcome: Synthesis
Purification
Preparative HPLC and SFC purification, including chiral separations, to reach the purity your project requires.
Outcome: Purification
Characterization & Certificate of Analysis
Identity and purity confirmed by NMR, LC-MS, HPLC, and GC-MS, documented in a Certificate of Analysis.
Outcome: Quality Confirmed
Delivery & Scale-Up
Timely delivery of the quantity you need, with a route ready to hand over to process development for larger batches.
Outcome: Delivered
Explore in detail
Technical resources
Open a section to explore our full service scope and instrumentation.
Methods & service scope17 areas of expertise
- Asymmetric Synthesis and Resolution of chiral compounds
- Bioconjugate chemistry
- Boronic acid synthesis and couplings
- Carbohydrates, Polysaccharides & Glycoconjugates
- Catalytic hydrogenation
- Chiral synthesis and Chromatographic separations
- Fatty acid analogues and Phospholipids
- Fluorescent Labelled drug conjugates
- General organic and small molecule synthesis
- Heterocyclic chemistry
- Macromolecules, Natural products, Bioactive Molecules, Metabolites / impurities
- Natural products synthesis
- Organo-metallic chemistry
- Peptides & Unnatural Amino Acids, Peptidomimetics
- Photochemistry
- High pressure reactions
- Synthesis of high potency compounds
Instrumentation & platforms3 instruments and capabilities
- Advanced Synthetic Methodologies (Photochemistry & Electrochemistry, Parallel Synthesis Platforms, Flow Chemistry)
- High-Throughput Preparative HPLC Autopurification System
- Structural Biology & Analytical Technologies (NMR, LC-MS/MS, Solid-State Chemistry)
Let’s work together
The right expertise.
For your next step.
Talk with our scientific team about your requirements,
technical feasibility, and timelines.
What happens next
- Share your requirementsTell us about your research goals, scope, and timelines.
- Scientific consultationOur scientists review feasibility and discuss the best approach with you.
- Proposal and quoteReceive a clear proposal covering scope, deliverables, timelines, and cost.