Co-crystal Screening
Choose suitable co-formers to design experiments; Co-crystal form identification and characterization; Thermodynamic phase relationship study; Stability and solubility evaluation; Co-crystal form recommendation.
Chemistry R&D
Co-Crystal & Salt Screening
Explore co-crystal, salt, and polymorph screening to understand and optimize the solid-state properties of your compounds.
- Salt screening
- Co-crystals
- Polymorphs
The science
Service overview
We provide co-crystal, salt, and polymorph screening to identify, characterize, and select the optimal crystal form of Active Pharmaceutical Ingredients (APIs). These platforms enhance drug solubility, stability, and bioavailability, and support intellectual property (IP) protection and regulatory compliance. Selecting the optimal solid form of an API during early drug development can mitigate the risk of failure later in development. Our expert R&D team provides specialized consulting and laboratory services to guide these processes from discovery through clinical phases.
How we can help
Our capabilities
Explore the services and methods available for your project.
Salt Screening
Design various salt-forming experiments according to the physicochemical properties of compound; Salt form identification and characterization; Thermodynamic phase relationship study; Stability and solubility evaluation; Salt type selection and salt form recommendation.
Polymorph Screening
Design various crystallization conditions according to the physicochemical properties of compound; Crystal form identification and characterization; Thermodynamic phase relationship study; Stability and solubility evaluation; Optimal solid form recommendation.
How a project runs
Research workflow
4 stages, with a clear outcome at each step.
Experimental Design & Co-Former/Salt Selection
Designing co-crystal, salt, or polymorph screening conditions based on API physicochemical properties.
Outcome: Screening Matrix
Screening Execution & Form Identification
Executing crystallization screens (Crystal16) and identifying crystalline forms via PXRD, DSC, TGA, and Raman/FT-IR.
Outcome: Form Identification
Thermodynamic Phase & Stability Evaluation
Evaluating thermodynamic phase relationships, solubility profiles, and DVS hygroscopicity.
Outcome: Thermodynamic Stability
Optimal Solid Form Recommendation & IP Guidance
Recommending the optimal solid form for development and providing data packages for IP protection and regulatory compliance.
Outcome: Optimal Form Nomination
Explore in detail
Technical resources
Open a section to explore our full service scope and instrumentation.
Methods & service scope4 areas of expertise
- Solubility & Bioavailability Enhancement
Identify and select optimal crystal forms to significantly enhance drug solubility, dissolution rates, and in-vivo bioavailability.
- Intellectual Property (IP) Protection & Form Recommendation
Secure solid-state IP boundaries through novel co-crystal, salt, and polymorph form identification and recommendation.
- Early-Stage Risk Mitigation
Mitigate the risk of solid-state phase transformation failures early in drug discovery through specialized screening.
- Thermodynamic Phase & Stability Evaluation
Comprehensive thermodynamic phase relationship studies, hygroscopicity testing, and long-term stability evaluation.
Instrumentation & platforms7 instruments and capabilities
- Powder X-ray Diffraction (PXRD) - Fast, automated identification of crystalline phases
- Differential Scanning Calorimetry (DSC) & Thermal Gravimetric Analysis (TGA) - Thermal stability & melting points
- Raman and FT-IR Spectroscopy - Molecular structure crystal form differentiation
- Nuclear Magnetic Resonance (NMR) - Solid-state characterization
- Inductively Coupled Plasma Mass Spectrometry (ICP-MS) - Salt counterion & trace metal quantification
- Dynamic Vapor Sorption (DVS) - Assesses hygroscopicity
- Crystal16 Crystallization Workstation - Wide-range solvent, concentration, and cooling rate exploration with minimal compound
Let’s work together
The right expertise.
For your next step.
Talk with our scientific team about your requirements,
technical feasibility, and timelines.
What happens next
- Share your requirementsTell us about your research goals, scope, and timelines.
- Scientific consultationOur scientists review feasibility and discuss the best approach with you.
- Proposal and quoteReceive a clear proposal covering scope, deliverables, timelines, and cost.