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Specialist expertise

Chemistry: Lead Optimization & ADC Design

Custom conjugate design and linker-payload optimization.

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The science

About this capability

Lead optimization and antibody-drug conjugate (ADC) design are critical, iterative phases in drug discovery that combine antibody engineering, linker chemistry, and cytotoxic payload selection to refine the ADC structure for better efficacy and safety.

Technical scope

  • Custom Conjugate Design: Tailor ADCs to your targets, ensuring linker stability, payload potency, and therapeutic stability.
  • Optimization of Linker-Payload and Conjugate: Refine linker-payload and bioconjugation chemistry using advanced technologies (Site-specific conjugation, Next-Generation linker, and Multifunctional conjugation platforms).

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Strategic Consultation & Discovery Planning

Structured, multi-disciplinary approach to turn a therapeutic target into a viable clinical candidate through target validation and customized roadmap planning.

Target Identification & Therapeutic Candidate Screening

Identifying disease-associated molecules (proteins, receptors) and selecting high-affinity antibodies through in-vivo/in-vitro screening.

Proof of Concept (POC) Studies

Early-stage preclinical assessments validating candidate antibody binding affinity, target specificity, functional efficacy, and stability.

In-Vitro & In-Vivo Validation

Transitioning candidates from initial binding screens to functional development via in-vitro bioassays and in-vivo tumor xenograft studies.

Preclinical Development

Optimizing lead antibodies through affinity maturation, humanization, and Fc engineering, and scaling up conjugation processes.

Regulatory Support & IND Application

Ensuring compliance with FDA guidelines from target validation to IND submission, including QTPP, mAb characterization, and CMC compliance.

Let’s work together

The right expertise.
For your next step.

Talk with our scientific team about your requirements,
technical feasibility, and timelines.

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+1 604-339-3244

What happens next

  1. Share your requirementsTell us about your research goals, scope, and timelines.
  2. Scientific consultationOur scientists review feasibility and discuss the best approach with you.
  3. Proposal and quoteReceive a clear proposal covering scope, deliverables, timelines, and cost.