Specialist expertise
In-Vivo Pharmacokinetics & Pharmacodynamics
Advanced platforms for PK analysis including LC/MS, HPLC, Flow Cytometry, and qPCR.
The science
About this capability
In-vivo PK and PK/PD studies determine ADME properties and deliver key parameters such as clearance, volume of distribution, half-life, and bioavailability, alongside insight into candidate efficacy.
Technical scope
- Assay Development and Validation: Designing and testing specific, precise assays (e.g., ELISA, MSD, SPR) to measure biomarkers, proteins, or genetic markers in preclinical and clinical samples.
- PK/PD Modeling and Simulation: Integrating pharmacokinetic (drug concentration) and pharmacodynamic (drug effect) data to establish dose-response relationships, determine therapeutic windows, and predict clinical outcomes.
- Biomarker Analysis: Evaluating molecular and cellular effects (e.g., gene expression, receptor occupancy) to demonstrate target engagement and pharmacological activity.
- Drug Interaction Studies: Assessing how drugs interact with receptors, pathways, or other compounds.
Let’s work together
The right expertise.
For your next step.
Talk with our scientific team about your requirements,
technical feasibility, and timelines.
What happens next
- Share your requirementsTell us about your research goals, scope, and timelines.
- Scientific consultationOur scientists review feasibility and discuss the best approach with you.
- Proposal and quoteReceive a clear proposal covering scope, deliverables, timelines, and cost.