Blood Test

The ability to deliver drug products to a patient in a safe, efficient and cost-effective manner depends largely on the physicochemical properties of the active pharmaceutical ingredient (API) in the solid-state. The pharmaceutical industry has encountered a large number of drugs with poor physicochemical properties leading to variable pharmacokinetic properties that were unsuitable for marketing as drug products. The following is a list of physicochemical properties that can be influenced by the stressful conditions used in the manufacturing and handling of APIs in the pharmaceutical industry.

• API purity and related substances
• Partition coefficient
• Acidity constant (pKa)
• Solubility/ Dissolution
• Particle size/ Surface area
• Crystal properties - crystallinity, polymorphism
• Chemical stability
• Physical stability
• Compatibility with excipients

 
Qualified pharmaceutical development scientists at Pharma Inventor Inc. can assist you in optimizing these API properties using up-to-date techniques such as, Co-crystallization, Crystallization and Salt screening.

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